Etymologically

ἀντίδοτος

Etymology and origin of the Ancient Greek word ἀντίδοτος

Confidence
Established
Formation
Derivation
First attested
100 BC–100 AD Strabo, Geography More words from the 1st century BC
Ultimate origin
Ancient Greek ἀντιδίδωμι

Pronunciation

  • 5th-century BC Attic: /an.tí.do.tos/[1]
  • 4th-century AD Koine: /anˈti.ðo.tos/[1]
  • 10th-century Byzantine: /anˈti.ðo.tos/[1]

Forms

ᾰ̓ντῐ́δοτος (antídotos) m or f (neuter ᾰ̓ντῐ́δοτον); second declension[1]

Etymology

It is a verbal adjective from Ancient Greek ἀντιδίδωμι (antidídōmi, “to give in return, give instead”) + -τος (-tos), meaning “given in place of” or “given against”.[1][2][3] The verb is made of ἀντί (antí, “against, instead of”) and δίδωμι (dídōmi, “to give”).[3][4]

Used as a feminine noun, it is short for a phrase with δόσις (dósis, “dose”) understood, a remedy “given against” a poison or illness.[2][5] Etymonline explains it instead as short for a phrase with φάρμακον (phármakon, “drug”).[3]

Earliest recorded meaning

The earliest text with the word in the GLAUx corpus is Strabo's Geography, which has the plural.[6] In the 1st century AD Dioscorides' De materia medica uses it for a remedy against poison.[6][4]

Semantic evolution

As an adjective it meant “given in place of”, with a genitive: an epigram by Palladas speaks of something given in place of fire,[2][7] and another epigram calls a thing a “remedy of ills”.[2][7] Nonnus also uses it for “given in return”.[7]

As a noun it is the medical antidote, from Strato's epigrams and Plutarch on; the gender is often uncertain, but it is feminine in Strato.[2][7] Galen asks what an antidote is and says that a drug is called by that name.[7] LSJ records a diminutive, ἀντιδότιον (antidótion), in Archigenes.[2]

Christian writers used it in a figurative sense: Ignatius of Antioch calls the bread of the Eucharist “an antidote against dying”,[4] and Clement of Alexandria pictures the Word as a physician who brings the sick every antidote of salvation.[7]

Latin borrowed the word as Latin antidotum or antidotus, and through Old French and Latin it gave the English word antidote in the early 15th century.[3] Modern Greek αντίδοτο (antídoto) is a learned form of Hellenistic ἀντίδοτον; it means an antidote and, figuratively, anything that counters something unpleasant.[8][9]

Timeline

  • 1st century BC to 1st century AD – Strabo has it in the earliest text of the GLAUx corpus.[6][7]
  • 1st century AD – Dioscorides uses it for a remedy against poison.[4][6][7]
  • 1st–2nd century AD – Plutarch uses it as a noun, an antidote.[2][4][7]
  • 1st–2nd century AD – Ignatius of Antioch calls the Eucharist an antidote against death.[4][7]
  • 2nd century AD – Galen discusses what an antidote is.[7]
  • 2nd–3rd century AD – Clement of Alexandria speaks of the antidotes of salvation.[7]
  • 4th–5th century AD – Palladas uses the adjective for something given in place of fire.[2][7]
  • Early 15th century – English borrows it, through Latin and Old French, as antidote.[3]
  • Modern Greek – The learned αντίδοτο (antídoto) means an antidote, literal or figurative.[8][9]

Meanings

Adjective

  1. Given in place of something (with a genitive).[2][7]
  2. Given as a remedy for something (with a genitive).[2][7]
  3. Given in return.[7]

Noun

  1. An antidote, a remedy against poison or disease.[2][4][7]
  2. (figurative, Christian) A remedy, as in “an antidote against dying”.[4][7]

Word family

  • ἀντιδότιον (antidótion)

References

  1. ^ a b c d e Wiktionary, the free dictionary, https://en.wiktionary.org
  2. ^ a b c d e f g h i j k Liddell, Henry George; Scott, Robert; Jones, Henry Stuart (1940), A Greek-English Lexicon, 9th ed., Oxford: Clarendon Press
  3. ^ a b c d e Harper, Douglas. Online Etymology Dictionary, https://www.etymonline.com
  4. ^ a b c d e f g h Bauer, Walter; Danker, Frederick W., et al. (2000), A Greek-English Lexicon of the New Testament and Other Early Christian Literature, 3rd ed., Chicago: University of Chicago Press
  5. ^ Pape, Wilhelm (1914), Griechisch-deutsches Handwörterbuch, 3rd ed., rev. Max Sengebusch, Braunschweig: Vieweg
  6. ^ a b c d Keersmaekers, Alek (2021–2025), GLAUx: The Greek Language Automated corpus, https://github.com/alekkeersmaekers/glaux
  7. ^ a b c d e f g h i j k l m n o p q r Rodríguez Adrados, Francisco, et al., eds. (1980–), Diccionario Griego-Español, Madrid: CSIC, http://dge.cchs.csic.es/xdge
  8. ^ a b Ινστιτούτο Νεοελληνικών Σπουδών (Ίδρυμα Μανόλη Τριανταφυλλίδη) (1998), Λεξικό της κοινής νεοελληνικής, Thessaloniki: Aristotle University of Thessaloniki
  9. ^ a b Babiniotis, Georgios (2010), Ετυμολογικό λεξικό της νέας ελληνικής γλώσσας [Etymological Dictionary of Modern Greek], Athens: Κέντρο Λεξικολογίας
Cite this entry

“Ἀντίδοτος.” Etymologically, 8 Nov. 2026, etymologically.com/grc/%E1%BC%80%CE%BD%CF%84%CE%AF%CE%B4%CE%BF%CF%84%CE%BF%CF%82. Accessed 8 Nov. 2026.

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